
BUYER’S GUIDE · RWE, HEOR & MEDICAL AFFAIRS
Choose a governed environment for real-world data.
Evaluate AI-enabled trusted research environments for the claims, EMR, lab, registry and study data your team already licenses. A practical guide to five decisions that shape the path from question to evidence.
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Compare five areas: AI-enabled analysis, licensed datasets and cloud, governance, partner workspaces, and analyst tools.
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Take vendor questions and a one-page evaluation checklist into your next platform conversation.
Get the buyer’s guide
INSIDE THE GUIDE
Five decisions before you choose.
Move beyond feature lists. Use these five areas—and the questions in each chapter—to test how an environment supports your evidence team’s actual work.

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Get from question to answer faster: visible cohort filters, inspectable AI steps and agents for recurring analysis.
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Work across licensed datasets in your own cloud: multiple sources, provenance, compute visibility and provider independence.
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Make analyses audit-ready: access logs, reproducibility, license restrictions and end-of-term deletion.
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Collaborate without shipping extracts: granular, time-limited partner workspaces with projects and code in one place.
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Give every analyst the right tools: R, Python and SAS alongside guided workflows your team can reuse.
A PRACTICAL EVALUATION TOOL
Bring better questions to every vendor.
Each of the five sections ends with questions to ask any vendor—including Manifold. The final checklist puts the criteria on one page so your RWE, HEOR and Medical Affairs team can compare answers side by side.
Start with the analysis your team needs to deliver, then ask how the environment keeps data access, cohort work, review and partner collaboration governed in one place.
